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KMID : 0895820130230020073
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Journal of Oriental Rehabilitation Medicine
2013 Volume.23 No. 2 p.73 ~ p.83
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Effect of Foeniculum Vulgare extract on inflammatory response in lipopolysaccharide exposed rats
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Heo Seong-Kyu
Lee Eun
Park Won-Hyung
Cha Yun-Yeop
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Abstract
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Objectives :This study was performed to investigate the effects of Foeniculum Vulgare(FV) extract on the anti-inflammatory of lipopolysaccharide(LPS) exposed rats.
Methods : We divided LPS exposed Sprague-Dawley rats into 4 groups. They were control group, feed with 100 mg/kg, 200 mg/kg, 300 mg/kg FV groups. They were administered for 6 weeks. We measured the concentration of plasma interleukin-1β(IL-1β), plasma interleukin-6(IL-6), plasma tumor necrosis factor-α(TNF-α), plasma interleukin-10(IL-10), the concentration of liver IL-1β, IL-6, TNF-α and IL-10.
Results : 1. Plasma IL-1β, plasma IL-6 and plasma TNF-α concentration increased rapidly at 2hours after LPS injection and maintained high levels at 5hours after LPS injection. The concentration of these cytokines in the FV extract groups showed lower values than control group(P<0.05).2. The concentration of Plasma IL-10 in FV extract groups showed higher values than control group at all times(P<0.05). 3. The concentration of liver IL-1β and IL-6 in FV extract groups showed lower values than control group(P<0.05). The concentration of liver TNF-α in FV extract groups showed a tendency to decrease and that of liver IL-10 in FV extract groups showed a tendency to increase; however, these values showed no significantly different.
Conclusions : In inflammatory response by LPS derivation, the FV gives positive effect.
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KEYWORD
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Foeniculum Vulgare, Lipopolysaccharide, Inflammatory response, Cytokine
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